Epidemiology Research Today is a free monthly online journal that collates and summarizes the latest research about Epidemiology, including details on twin studies, statistics, environmental and genetic factors.

Molecular Epidemiology of HIV Type 1 in Inner Rio De Janeiro State, Brazil.

Eyer-Silva WA, Couto-Fernandez JC, Morgado MG

Laboratório de Aids and Imunologia Molecular, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Programa Municipal de HIV-1/Aids de Santo Antonio de Pádua, Rio de Janeiro State, Brazil.

In the State of Rio de Janeiro, Brazil, HIV-1 diversity surveys have been performed mainly in the capital, and little is known about HIV-1 molecular epidemiology in small, inner cities. We studied 87 polymerase sequences recovered from 2 different studies conducted in inner cities of Rio de Janeiro State: a cross-sectional survey of patients receiving care in the small city of Santo Antonio de Pádua, and a case series of patients who were failing HAART in 26 additional inner cities throughout the State. Subtypes B (83.9%), F1 (8%), D (2.3%), and unique BF1 recombinants (5.7%) were demonstrated. The cross-sectional study found that 41.6% of the patients harbored genetically related strains that fell within clusters and probably took part in the same chain of viral spread. These clusters were phylogenetically unrelated to previously reported clusters from a neighboring city, suggesting that each small city harbors its own set of microepidemic lineages.

Published 2 March 2007 in AIDS Res Hum Retroviruses, 23(2): 303-308.
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