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Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in The Netherlands.

Niks EH, Kuks JB, Verschuuren JJ

Department of Neurology, J3-R 166, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. ehniks@lumc.nl

The epidemiology of myasthenia gravis subtypes and the frequency of antibodies to muscle-specific kinase (MuSK) was studied in patients with generalised myasthenia gravis without anti-acetylcholine receptor antibodies who had an onset of symptoms between 1990 and 2004 in a well-defined region in The Netherlands. The nationwide prevalence and incidence of myasthenia gravis with anti-MuSK antibodies were also studied. MuSK antibodies were found in 22% of patients with generalised myasthenia gravis without anti-acetylcholine receptor antibodies. Nationwide, 35 patients with MuSK myasthenia gravis were identified, yielding a prevalence of 1.9 per million (95% confidence interval (CI) 1.22 to 2.59) and an annual incidence 0.10 per million person-years (95% CI 0.06 to 0.14).

Published 19 March 2007 in J Neurol Neurosurg Psychiatry, 78(4): 417-8.
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